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  • Romain Glerup posted an update 1 month, 4 weeks ago

    0ADG7 [36 ] P62617 [55 ] P14900 [32 ] B1J028 [42 ] M8X9N5 [30 ] P0AD61 [51 ] P0A858 [44 ] Human Q96RQ3 [48 ]DrugBank prospective inhibitorsc LZJ, LZK, LZL, OA1, OA2, OA3, OA4, OA5, L21, L22, L23 (P24182 [53 ]); BTI (Q99UY8 [48 ]); BTN (P11498 [45 ]); D1L, H1L (O00763 [32 ])P54819-2 [45 ] IPE (P30085 [32 ]) P30084 [44 ] QUE (Q6NVY1 [30 ])Q9NWU1 [45 ] CER, P9A, PMN (P0AAI5 [50 ]); TL5, TL6, P4T (P0A953 [38 ]); TLM (P63454 [37 ]) P20839 [35 ] P20839 [35 ] Q5T2R2 [31 ] CER, 669, OCS (P0A6R0 [45 ]); B82 (820 T1 [43 ]); DCC, UDT, VZZ, D1T, DFD, MDX (P0A574 [37 ]) QUE, 2BC, 2BE, 2RB, 3BE, 4BB, 4BE, AGI, EMO, SAK (Q5G940 [41 ]); BDE (O25928 [41 ]) P21 (P43889 [42 ]) MOA, RBV, CPR, VX-148 (P20839 [35 ]) IPR (Q83M58 [41 ]) DMA, IPE (P62624 [30 ])P14618-2 [44 ] FPP (Q8EBR3 [62 ]); GPP (P62617 [55 ]); IPP (A0R559 [34 ]) P60174-1 [44 ] LK1, LK2, LK3, LK4, LKM (P14900 [32 ]); P38606 [51 ] P21281 [53 ] ADH, 911, Tiludronate, BafilomycinA1, Bafilomycin B1 (P38606, [51 ]); QUE, APP, AUR, PIT, TLX (P06576 [30 ]) Gallium nitrate, AES (P21281 [53 ]); QUE, APP, AUR, PIT, TLX (P06576 [30 ])A0A029KL96 [52 ] P14618-2 [44 ] D8G, DYY, DZG, PGA (P14618 [44 ]) L3ICZ2 [46 ] P33898 [61 ] N3Z8L0 [36 ] P0A9B2 [52 ] P25526 [35 ] P0A825 [56 ] P0A825 [48 ] P00491 [48 ] P04406 [44 ] Q92506 [33 ] O14556 [47 ] P00352 [35 ] IMH, 2DI, AZG, 9PP, IMG, GU7, BC3, 9DI (P00491 [48 ]) EMO (P16544 [37 ]); TAQ, CB3, DVP, FE1 (P0CG22 [34 ]); MAX (Q6PKH6 [33 ]); TDB (Q16698 [31 ]) TCL, IDN, AYM, BGC, 654, ZAM, 826, NDT, (P0AEK4 [39 ejn.13226 ]); NAP, TDB (Q16698 [30 ]) BRZ, zookeys.576.8177 NMD, TND (O14556 [44 ]); AES (P04406 [49 ]) APR, SND, AES (P04406 [49 ]); BRZ, NMD, TND (O14556 [47 ])P34897-3 [45 ] B08, B28, B29, B76, FPP, FPS, IPE (P60472 [44 ]); GPP (P60379 [43 ]) P34897-3 [41 ] PLP, THL (P34897 [45 ]); Mimosine (P34896 [44 ]) B7ZLW7 [31 ] Q96RQ3 [48 ] B7Z609 [51 ] Q6IAV5 [42 ] Q9NRG1 [33 ] P00492 [34 ] P51648 [43 ] PLP, THL (P34897 [41 ]); Mimosine (Pr4896 [40 ]) CNC, THL, I2A (Q99707 [31 ]) SIN, EMT (P55809 [52 ]) SIN, EMT (P55809 [42 ]) DX4, PPO, PM6, PRP, XMP, 9DG (P00492 [34 ]) DX4, PPO, PM6, PRP, XMP, 9DG (P00492 [34 ]) RLT, 1O8, DTT (P00352 [30 ]);CD0727 (folD | fhs | fchA)d P24182 [53 ] scoB (folD | fhs | fchA) E9YQ86 [56 ] G1YD51 [53 ] W1H7G6 [47 ] W1H7G6 [55 ] scoA (folD | fhs | fchA)d CD3231 (hpt) hpt (CD3231) aldh (CD2733)aGenes which are vital as part of a double mutant pair have the name from the partner gene identified in parenthesis. b Uniprot ID with the closest sequence homolog. c 3-letter PDB code of Afatinib (dimaleate) supplier ligand that may be a identified inhibitor or binder of a sequence homolog together with the Uniprot ID plus the degree of sequence identity offered in parenthesis. Authorized drugs are in italics. d The target gene is part of far more than 1 necessary pairs, one particular with every single with the proteins in parenthesis.missing info in each and every database [64-66], the noncurated network resulting from the simple aggregation of all these sources of facts is generally incomplete and includes a big s10620-016-4058-9 quantity of errors, missing data and repetitions, which make the generated networks unusable [41]. Various databases will generally have various identifiers for very comparable entries, which bring about duplications. Surprisingly, this really is accurate not simply for reactions and metaboliteswhere curation is far more complicated but additionally for genes. Manual curation is crucial to correct inaccuracies present in metabolic databases and specifically to fill gaps (missing reactions) essential to take away dead-end metabolites to create a functional network. Manual curat.